Premium
Surface structure of antral gastric mucosa represents the status of histologic gastritis: Fundamental evidence for the evaluation of antral gastritis by magnifying endoscopy
Author(s) -
Kim Sunjin,
Ito Masanori,
Haruma Ken,
Egi Yasuo,
Ueda Hiroyuki,
Tanaka Shinji,
Chayama Kazuaki
Publication year - 2006
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2006.04193.x
Subject(s) - gastritis , medicine , antrum , biopsy , endoscopy , helicobacter pylori , gastric mucosa , gastroenterology , pathology , chronic gastritis , h&e stain , stomach , staining
Background: Recent studies have demonstrated the diagnostic potential of magnifying endoscopy in cases of histologic gastritis. The aim of the present study was to clarify whether the mucosal surface structure reflects the degree of histologic gastritis below the surface. Methods: Gastric biopsy specimens were obtained from 1018 Japanese patients and were stained with hematoxylin and eosin. In 863 sections examined, gastritis was graded by means of the updated Sydney system, and the surface structure was classified as one of four types: flat, irregular, papillary, or non‐structured. In addition, 103 patients underwent gastric examination by magnifying gastroscopy. Results: The surface structure of most biopsy sections with normal mucosa and no Helicobacter pylori infection was classified as the flat type. Grades of histological gastritis were statistically lower in flat‐type sections than in other types. Histologic gastritis was found in 91% of sections with a non‐flat surface structure. Helicobacter pylori infection was confirmed in 96% of these cases. Most biopsy sections in patients with abnormal magnifying endoscopy features were of the non‐flat type and showed histologic gastritis. Conclusions: The surface structure of the gastric mucosa reflects the status of histologic gastritis. Magnifying gastroscopy could be a useful non‐invasive method of diagnosing histologic gastritis.