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Pathobiology of hepatobiliary neoplasms in children
Author(s) -
ZIMMERMANN ARTHUR
Publication year - 2004
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2004.03706.x
Subject(s) - hepatoblastoma , medicine , hepatocellular carcinoma , pathology , phenotype , gene , biochemistry , chemistry
Several types of malignant epithelial liver tumors are recognized in infants, children and young adolescents. These neoplasms mainly include hepatoblastoma and its types and subtypes, whereas hepatocellular carcinoma is very rare in this age group. A pathology classification of hepatoblastomas has been worked out over the years, although some of the subtypes listed are still not sufficiently defined. Moreover, reviews of cases within large clinical trials have shown that an increasing number of pediatric hepatic tumors deviate from the phenotypes found in current classifications. The present overview refers to some of these apparently novel and intriguing lesions.