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Pathogenesis of cirrhosis
Author(s) -
WANLESS IAN R
Publication year - 2004
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2004.03705.x
Subject(s) - medicine , cirrhosis , hepatic veins , parenchyma , pathogenesis , pathology , portal vein , extinction (optical mineralogy) , fibrosis , stroma , blood supply , portal venous pressure , portal hypertension , radiology , surgery , gastroenterology , paleontology , immunohistochemistry , biology
Cirrhosis develops by the accumulation of many focal lesions of parenchymal extinction. Parenchymal extinction is accompanied and presumably caused by obliteration of small portal and hepatic veins. Fibrosis occurs during the acute phase of injury but is rapidly removed leaving collapsed preformed stroma and obliterated small veins. Portal vein supply is replaced by arterial flow. Dominant arterial flow may prevent healing of extinction lesions and restoration of obliterated portal veins.