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Chronic hepatitis B or C in HIV‐infected persons: pathogenesis and management
Author(s) -
THIO CHLOE L
Publication year - 2004
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2004.03665.x
Subject(s) - medicine , pathogenesis , liver disease , hepatitis b virus , immunology , hepatitis c virus , viral disease , hepatitis b , virology , human immunodeficiency virus (hiv) , hepatitis c , disease , virus
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are common in HIV‐infected individuals due to shared routes of acquisition. In the era of effective HIV therapeutics, the long‐term consequences of these infections are becoming apparent with liver disease emerging as a leading cause of morbidity and mortality. The pathogenesis of these hepatotropic viruses is altered in the setting of HIV‐infection as demonstrated by decreased rates of HBV and HCV clearance and increased rates of liver disease progression. Treatment of these chronic viral infections in HIV‐infected individuals is complex and the available treatment options have low response rates. Thus, improved treatments and more studies are needed in order to determine the optimal management of HIV‐infected patients co‐infected with HBV or HCV.