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Hepatitis C viral kinetics
Author(s) -
HERRMANN EVA,
SARRAZIN CHRISTOPH
Publication year - 2004
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2004.03664.x
Subject(s) - ribavirin , medicine , interferon , viral hepatitis , hepatitis c virus , pegylated interferon , hepatitis c , antiviral therapy , viral load , virology , immunology , host factors , virus , chronic hepatitis
Standard therapy with (pegylated) interferon‐alfa and ribavirin still leads to sustained virologic response rates of 50–60%, only. Therefore, new therapeutic strategies are required. With the analysis of mathematical models of hepatitis C viral kinetics, individual kinetic rates as infected cell loss, clearance of free virus, and an efficiency factor on blocking viral production can be estimated. They can be used to summarize and quantify the initial response to antiviral therapy and, furthermore, allow the assessment of treatment mechanisms, prediction of treatment response, and the efficient identification of viral and host factors on treatment response. They may even be used for optimizing and individualizing therapy.