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Structural and functional analysis of full‐length hepatitis B virus genomes in patients: Implications in pathogenesis
Author(s) -
WEN YUMEI
Publication year - 2004
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2003.03158.x
Subject(s) - hepatitis b virus , genome , immunogenicity , pathogenesis , virology , asymptomatic , medicine , virus , orthohepadnavirus , viral pathogenesis , genetics , biology , hepadnaviridae , computational biology , immunology , gene , viral replication , antigen , pathology
The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full‐length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome‐based studies in elucidating the pathogenesis of HBV infections. Comparison of structural and functional characteristics of viral genomes isolated from various geographical regions might contribute to explaining the differences in HBV clinical manifestation and prognosis in different geographical regions.