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Gene therapy: Recent advances and applications in gastroenterology and hepatology
Author(s) -
OUYANG EDWIN C,
WU GEORGE Y
Publication year - 1998
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1998.tb01867.x
Subject(s) - medicine , hepatology , gastroenterology , general surgery
Abstract The advantages and disadvantages of viral and non‐viral vectors for gene delivery are reviewed. Advances in systems for introduction of new gene expression are described, including self‐deleting retroviral transfer vectors, chimeric viruses and chimeric oligonucleotides. Systems for inhibition of gene expression are also discussed including antisense oligonucleotides, ribozymes and dominant‐negative genes. Examples of the use of these systems in animal models and clinical trials for gastrointestinal disorders are discussed.