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Acute in vivo effect of octreotide acetate, a somatostatin analogue on the cellular function of gastric mucosa in the rat
Author(s) -
MOTEGI MASAHIKO,
NAGAMACHI YUKIO,
KANEKO TETSUYA,
MATSUZAKI SHIGERU
Publication year - 1998
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1998.tb00641.x
Subject(s) - gastrin , octreotide , somatostatin , medicine , pentagastrin , endocrinology , enterochromaffin like cell , bombesin , histidine decarboxylase , parietal cell , subcutaneous injection , gastric mucosa , in vivo , gastric acid , stomach , secretion , neuropeptide , biology , receptor , biochemistry , microbiology and biotechnology , amino acid , histidine
Somatostatin is known to suppress various cellular functions of the gastrointestinal tract. In the present study, octreotide acetate, a synthetic long‐acting somatostatin analogue was tested for its effects on some cellular functions of gastric mucosa. Octreotide raised the gastric mucosal pH within 1 h after a single subcutaneous injection to rats at doses of 1–100 μg/kg bodyweight. Serum gastrin levels increased transiently at a dose of 10 μg/kg bodyweight but not at 100 μg/kg. Basal levels of serum gastrin were not affected, while famotidine‐induced gastrin secretion was suppressed by octreotide at a single dose of 100 μg/kg. The increase in the intragastric acidity and histidine decarboxylase activity following pentagastrin treatment was significantly reduced by octreotide. These results suggested that this somatostatin analogue inhibits the function of not only the parietal cell and G cell but also the enterochro‐maffin‐like (ECL) cell, resulting in intraluminal hypoacidity.