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Recent developments in autoimmune liver diseases
Author(s) -
MANNS MICHAEL P
Publication year - 1997
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1997.tb00509.x
Subject(s) - primary biliary cirrhosis , autoimmune hepatitis , medicine , primary sclerosing cholangitis , overlap syndrome , viral hepatitis , immunology , hepatitis , autoimmunity , liver disease , cirrhosis , antibody , disease , gastroenterology
Several diseases are regarded as autoimmune liver diseases. Apart from the cholestatic liver diseases, primary biliary cirrhosis, primary sclerosing cholangitis, these include autoimmune hepatitis, hepatitis as part of the autoimmune polyendocrine syndrome type 1 (APS‐1) and particular overlap syndromes such as autoimmune cholangitis (also called antimitochondrial antibody negative primary biliary cirrhosis [PBC]), overlap syndrome chronic active hepatitis (CAH)/PBC and the overlap syndrome primary sclerosing hepatitis (PSC)/CAH. In addition, auto‐antibodies may be observed during the course of chronic viral hepatitis, in particular chronic hepatitis C and D. Finally, a small number of drug‐induced liver diseases is immune mediated. The following article will review our recent progress in the field of autoimmune hepatitis including APS‐1 and autoimmunity in viral hepatitis and immune‐mediated drug‐induced liver disease.