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Radiological retrospective study of gastric cancer in humans: Two patterns of development in elevated type gastric cancer
Author(s) -
MIWA HIROTO,
IWAZAKI RYOZO,
OHKURA RYUICHI,
NAGAHARA AKIHITO,
MURAI TOSHIO,
OGIHARA TATSUO,
WATANABE SUMIO,
SATO NOBUHIRO
Publication year - 1997
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1997.tb00492.x
Subject(s) - medicine , cancer , pathological , group b , group a , gastroenterology , natural history , retrospective cohort study , pathology
A better understanding of the process of gastric cancer development would undoubtedly be helpful in diagnosis and treatment. However, there is little literature available concerning the natural history of elevated type gastric cancer in humans and this disease has not been systematically investigated. In this study the natural history of elevated type human gastric cancer was retrospectively investigated in 12 radiologically followed‐up patients. The cases were divided into two groups according to whether obvious abnormal findings were absent (group A, n = 5) or present (group B, n = 7) at initial examination. Clinico‐pathological features, including outcomes and DNA content of the tumours in both groups, were investigated and compared. Although the mean period between the initial and final examinations was significantly shorter in group A (19.6±11.7 months) than in group B (43.4±17.3 months), tumour size was significantly larger in group A (5.5±2.5 cm) than in group B (2.4±2.5 cm). Furthermore, group A showed deeper neoplastic cell invasion and worse outcomes. The DNA content of two cases in group A and four cases in group B was examined. One case in group A showed an aneuploid pattern, while all of those in group B showed a diploid pattern. These results indicate that the tumours in group A grew much faster than those in group B, which suggests the presence of two different patterns of development in elevated type gastric cancer.