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Effect of taurolithocholate‐3‐sulphate on biliary excretion of sulphobromophthalein and dibromosulphophthalein in the Eisai hyperbilirubinaemic rat
Author(s) -
TAKIKAWA HAJIME,
SANO NAOYO,
SATO AKIHIRO,
YAMANAKA MASAMI
Publication year - 1997
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1997.tb00478.x
Subject(s) - excretion , excretory system , medicine , endocrinology , transporter , bile salt export pump , chemistry , biochemistry , gene
We previously reported that biliary lithocholate‐3‐sulphate excretion was inhibited by dibromosulphophthalein, not by sulphobromophthalein in Eisai hyperbilirubinaemic rats (EHBR); instead its excretion was inhibited by both organic anions in control rats. In the present study, the effect of taurolithocholate‐3‐sulphate on the excretion of sulphobromophthalein and dibromosulphophthalein was studied in EHBR and control Sprague‐Dawley rats. Taurolithocholate‐3‐sulphate infusion inhibited biliary excretion of sulphobromophthalein and dibromosulphophthalein in both EHBR and control rats. These findings indicate that in control rats biliary excretion of taurolithocholate‐3‐sulphate is mediated by a carrier common for both organic anions, and that in EHBR, in which the canalicular multispecific organic anion transporter is impaired, the excretory pathway for taurolithocholate‐3‐sulphate is also partly identical to that for both organic anions.