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Relationship between interleukin‐8 levels and myeloperoxidase activity in human gastric mucosa
Author(s) -
SASAYAMA YOSHIAKI,
KAWANO SUNAO,
TSUJI SHINGO,
FUSAMOTO HIDEYUKI,
KAMADA TAKENOBU,
FUKUI HIROYUKI,
YONEDA SHOTARO,
OKISHIO TATSUO
Publication year - 1997
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1997.tb00392.x
Subject(s) - gastric mucosa , myeloperoxidase , medicine , infiltration (hvac) , helicobacter pylori , antrum , biopsy , pathology , gastroenterology , interleukin 8 , stomach , inflammation , physics , thermodynamics
Although interleukin (IL)‐8 is well known as a chemotactic agent for neutrophil migration in vitro , the relationship between IL‐8 activity and the degree of neutrophil infiltration in gastric mucosa is still unclear. In the present study, we investigated IL‐8 and myeloperoxidase activity, a marker of neutrophil infiltration, in gastric antral mucosa using biopsy samples in 23 patients with no gastric lesions. The results indicate that there is a good correlation between IL‐8 and myeloperoxidase activity (y = 0.173x + 13.9; r = 0.49, P <0.01). Furthermore, IL‐8 and myeloperoxidase activity are significantly higher in Helicobacter pylori ‐positive patients than in H. pylori ‐negative patients. In conclusion, an increase of IL‐8 activity in the gastric mucosa causes increased neutrophil infiltration in human gastric mucosa and H. pylori infection acclerates these reactions in the mucosa.