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Does Helicobacter pylori infection affect gastric emptying in patients with functional dyspepsia?
Author(s) -
GOH KL,
PARAMSOTHY M,
AZIAN M,
PARASAKTHI N,
PEH SC,
BUX S,
LO YL,
ONG KK
Publication year - 1997
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1997.tb00373.x
Subject(s) - gastric emptying , medicine , gastroenterology , helicobacter pylori , omeprazole , stomach , meal , helicobacter pylori infection , spirillaceae , gastritis
The objectives of the study were first, to determine if gastric emptying was altered in patients with functional dyspepsia with and without Helicobacter pylori infection compared with normal healthy volunteers; and second, to determine if there were further alterations in gastric emptying when the infection was eradicated. Gastric emptying was measured using a 99m technetium radiolabelled solid meal and gastric emptying time was measured as t 1/2 , viz. time taken for half the radiolabelled meal to be emptied from the stomach. The mean gastric emptying time for H. pylori‐positive patients ( n = 20) was 56.4±24.8 min; H. pylori‐negative patients ( n = 19) 67.8±31.8 min; and normal controls ( n = 20) 58.8 ± 18.8 min. No significant difference was obtained between the groups (ANOVA; P = 0.348). Thirteen of 18 H. pylori‐positive patients successfully eradicated the infection following treatment with omeprazole 40 mg o.m. and amoxycillin 500 mg t.d.s. for 2 weeks. The mean difference in the gastric emptying time before and H. pylori eradication was 23.9 + 13.2 min ( P = 0.556). There was no significant difference in the frequency of specific dyspeptic symptoms as well as the overall mean symptom score between the H. pylori‐positive and ‐negative patients. Gastric emptying was not different between patients with functional dyspepsia and normal controls. Helicobacter pylori infection does not appear to affect gastric emptying in patients with functional dyspepsia.