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Gastric mucosal energy metabolism and intracellular mucin content changes in patients with liver cirrhosis
Author(s) -
KAWANO SUNAO,
TANIMURA HIROHISA,
TSUJI SHINGO,
TAKEI YOSHIYUKI,
NAGANO KOUICHI,
KASHIWAGI TORU,
FUSAMOTO HIDEYUKI,
KAMADA TAKENOBU
Publication year - 1996
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1996.tb01387.x
Subject(s) - cirrhosis , mucin , intracellular , gastroenterology , medicine , energy charge , gastric mucosa , biopsy , metabolism , pathology , stomach , endocrinology , biochemistry , biology , receptor , adenylate kinase
Biopsy samples from patients with liver cirrhosis were investigated for changes in gastric mucosal energy metabolism and intracellular mucin content using high performance liquid chromatography and an image analysing system. The test group consisted of eight non‐cirrhotic patients with endoscopically normal mucosa (controls) and eight cirrhotic patients with oesophageal varices. The amount of ATP, energy charge level and intracellular mucin content were all significantly decreased in cirrhotic patients when compared with those of the controls. The decrease in energy charge also correlated well with the decrease in intracellular mucin content in the gastric mucosa. The results indicate that gastric mucosal energy metabolism is impaired in cirrhotic patients concomitantly with a decrease in the intracellular mucin content in the gastric mucosa. These changes may weaken defensive mechanisms against acid and NSAID, resulting in gastric mucosal injury in cirrhotic patients.