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C ase R eport : Primary splenic non‐Hodgkin's B cell lymphoma in a patient with chronic hepatitis C
Author(s) -
FUKUTOMI TAKAYOSHI,
FUKUSHIMA MARIE,
TANABE YUICHI,
HIROSHIGE KAICHIRO,
ITASAKA HIDETOSHI,
MATSUMATA TAKASHI,
KASAI NORIKO,
YOSHIDA KISAKU,
SUZUMIYA JUNJI,
KIKUCHI MASAHIRO,
YUFU YUJI,
SAKAI HIRONORI,
NISHIMURA JUNJI,
NAWATA HAJIME
Publication year - 1996
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1996.tb00321.x
Subject(s) - medicine , lymphoma , pathology , spleen , differential diagnosis , splenectomy , scintigraphy , hepatitis c virus , hepatitis , virus , immunology
A case of primary splenic lymphoma in a patient with chronic hepatitis C is reported. A 69‐year‐old man with chronic hepatitis C was admitted to Fukuoka City Hospital for evaluation of an enlarging splenic tumour. In the spleen, ultrasonographic examination revealed a hypoechoic tumour and computed tomography demonstrated a non‐enhancing low density area measuring 7 cm in diameter; coeliac angiography revealed a hypovascular tumour. Gallium scintigraphy showed uptake of the radioisotope in the splenic tumour. A splenectomy was performed and the morphological and immunohistochemical findings of this tumour were compatible with those of non‐Hodgin's B cell lymphoma. Recently, cases of malignant B cell lymphoma associated with hepatitis C virus infection have been reported. Lymphotropism of hepatitis C virus may play a pathological role in the development of non‐Hodgkin's lymphoma. We emphasize the importance of considering lymphoma in the differential diagnosis of extrahepatic disorders during the course of chronic hepatitis C virus infections.