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R eview : Diagnosis of Helicobacter pylori infection
Author(s) -
AZUMA T,
KATO T,
HIRAI M,
ITO S,
KOHLI Y
Publication year - 1996
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1996.tb00311.x
Subject(s) - medicine , rapid urease test , helicobacter pylori , phenol red , endoscopy , urea breath test , serology , biopsy , spirillaceae , cytology , gastroenterology , pathology , gastritis , helicobacter pylori infection , immunology , antibody , chromatography , chemistry
A number of diagnostic tests have been developed for the detection of H. pylori . Diagnostic techniques can be divided into invasive and noninvasive methods. The invasive methods require upper gastrointestinal endoscopy and involve culture of gastric biopsy specimens, examination of stained biopsies and detection of urease activity in the biopsies themselves. In addition, we have developed endoscopic diagnosis of H. pylori infection in gastric mucosa using phenol red dye‐spraying. The noninvasive methods include urea breath test and serological techniques. Although there has been considerable improvement in the techniques, a combination of at least two different techniques should be used in order to optimize the diagnostic yield. We recommend the use of one rapid test in the combination. The rapid urease test, cytology and the phenol red dye‐spraying endoscopy give results available before the patient leaves the endoscopy suite.