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Renal and haemodynamic responses to a novel kappa opioid receptor agonist, niravoline (RU 51,599), in rats with cirrhosis
Author(s) -
MOREAU RICHARD,
CAILMAIL STEPHANE,
HAMON GILLES,
LEBREC DIDIER
Publication year - 1996
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1996.tb00093.x
Subject(s) - diuresis , medicine , endocrinology , cirrhosis , free water clearance , agonist , opioid , urinary system , urine osmolality , renal function , kidney , receptor
Because renal water retention is a complication of cirrhosis, niravoline (RU 51,599), a novel kappa (κ) opioid receptor agonist which is known to cause a water diuresis under normal conditions, may be useful in the therapy of chronic liver diseases. Thus, the present study examined the effects of niravoline on renal function in rats with cirrhosis. Urine was collected during the 2 h period following the administration of vehicle (saline) in one group of animals or niravoline (3 mg/kg, i.v.) in auother group. Urinary and plasma osmolality were measured prior to and 2 h after niravoline in a third group of animals. Urine flow and natraemia were significantly higher after niravoline (147±12 μL/min and 153±2 mmol/L, respectively) than after vehicle (27 ± 7 μL/min and 146 ± 1 mmol/L, respectively). Niravoline significantly decreased urinary osmolality and significantly increased plasma osmolality and free water clearance. This substance did not significantly change urinary sodium excretion. In conclusion, this study shows that niravoline, a κ opioid receptor agonist, induced a water diuresis in rats with cirrhosis.