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Vasopressin plus oxygen vs vasopressin alone in cirrhotic patients with portal‐hypertensive gastropathy: Effects on gastric mucosal haemodynamics and oxygenation
Author(s) -
IWAO TADASHI,
TOYONAGA ATSUSHI,
SHIGEMORI HIROYUKI,
OHO KAZUHIKO,
SUMINO MICHIHIRO,
SATO MASAHIRO,
TANIKAWA KYUICHI
Publication year - 1996
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1996.tb00065.x
Subject(s) - vasopressin , medicine , oxygenation , portal hypertensive gastropathy , placebo , hemodynamics , perfusion , portal hypertension , endocrinology , gastroenterology , anesthesia , esophageal varices , cirrhosis , pathology , alternative medicine
The effects of vasopressin plus oxygen and vasopressin alone on gastric mucosal perfusion and oxygenation were studied using reflectance spectrophotometry and laser Doppler velocimetry in 23 cirrhotic patients with portal‐hypertensive gastropathy. The measurements were performed under basal conditions and after double‐blinded administration of placebo ( n = 7), vasopressin (0.3 U/min; n = 8) or vasopressin (0.3 U/min) plus nasal oxygen (4 L/min; n = 8). No significant effects on gastric mucosal haemodynamics and oxygenation were observed after placebo. In contrast, vasopressin and vasopressin plus oxygen induced a similar reduction in haemoglobin content (‐26 ± 2 and ‐21 ± 4%, respectively P < 0.01) and laser Doppler signal (‐23 ± 2 and ‐22 ± 2%, respectively, P < 0.01). Although each treatment induced a significant reduction in oxygen saturation (‐21 ± 2 and ‐7 ± 1%, respectively P < 0.01), the effect was less pronounced in patients receiving the combination than in those receiving vasopressin alone ( P < 0.01). These data suggest that vasopressin and vasopressin plus oxygen reduce gastric mucosal hyperaemia and that the oxygen supplement partially protects against gastric mucosal hypoxia during vasopressin infusion in cirrhotic patients with portal‐hypertensive gastropathy.