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Long‐term administration of natural interferon‐α in patients with chronic hepatitis C: Relationship to serum RNA concentration, HCV‐RNA genotypes, histological changes and hepatitis C virus
Author(s) -
KUMADA TAKASHI,
NAKANO SATOSHI,
TAKEDA ISAO,
SUGIYAMA KEIICHI,
OSADA TOSHIMASA,
KIRIYAMA SEIKI,
TOYODA HIDENORI,
SASA TOSHI,
SHIBATA MOTOHIRO,
MORISHIMA TSUNEO,
NAKANO ISAO,
FUKUDA YOSHIHIDE,
KOSAKA YOSHITANE,
TAMEDA YUKIHIKO,
NAKASHIMA MITSUYOSHI
Publication year - 1996
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1996.tb00054.x
Subject(s) - medicine , interferon , hepatitis c virus , virus , gastroenterology , interferon alfa , hepatitis c , genotype , alpha interferon , immunology , hepatitis , virology , biology , gene , biochemistry
To virologically assess the efficacy of interferon therapy in chronic hepatitis C, either 5 or 10 MU/day natural interferon‐α (IFNα) was administered to 57 patients with chronic hepatitis C for 38 weeks. A complete and sustained response (CR‐SR), as evidenced by the absence of serum hepatitis C virus (HCV)‐RNA during the administration period and at 6 months after the final administration of IFNα and a normal GPT level at 6 months after final administration, occurred in 42.6% (23/54) of subjects. Liver tissue was histologically evaluated using the histological activity index (HAI) score before and after the administration period. In CR‐SR cases, significant improvements ( P <0.01) occurred in periportal necrosis, intralobular necrosis, portal inflammation and total score. A comparison, by HCV genotypes, revealed that CR‐SR occurred in 60% (9/15) of subjects with type 2a and 30.3% (10/33) of subjects with type Ib. A comparison by virus concentration revealed that CR‐SR occurred in 71.4% (15/21) of those subjects having a virus concentration of < 10 5 copies/mL, but in only 24.2% (8/33) of those having a virus concentration of > 10 5 copies/mL. Analysis by a multiple logistic model revealed a strong correlation between the therapeutic effect of interferon therapy and the pre‐administration virus concentration ( P =0.0061) and genotype ( P =0.0015). These results suggest that the preadministration virus concentration and genotype are both key factors affecting the therapeutic effect of interferon therapy in chronic hepatitis C and that the therapeutic effect of interferon is satisfactorily high, irrespective of virus concentration, in subjects with type 2a HCV, but varies depending on virus concentration in subjects with type 1b.