Premium
Plasma endotoxin concentration and endotoxin binding capacity of plasma acute phase proteins in cirrhotics with variceal bleeding: An analysis by new methods
Author(s) -
FUKUI HIROSHI,
MATSUMOTO MUNESUKE,
TSUJITA SHIGENOBU,
TAKAYA AKIRA,
KOJIMA HIDEYUKI,
MATSUMURA MASAHIKO,
TSUJII TADASU
Publication year - 1994
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1994.tb01565.x
Subject(s) - transferrin , medicine , orosomucoid , varices , haptoglobin , acute phase protein , alpha (finance) , hemostasis , gastroenterology , cirrhosis , glycoprotein , endocrinology , surgery , biochemistry , chemistry , inflammation , construct validity , patient satisfaction
Plasma endotoxin levels in 12 cirrhotics with bleeding from oesophageal varices and 50 cirrhotics without bleeding were measured by the chromogenic assay after the pretreatment of sample by perchloric acid (HClO 4 ) and triethylamine. Endotoxin in cirrhotics with bleeding from varices was significantly higher than those without bleeding. In patients with bleeding, endotoxin increased for 3 days after the bleeding, first in the supernatant fraction and then in the precipitate fraction by HClO 4 treatment. Peak plasma α 1 ‐acid glycoprotein and haptoglobin were observed 3 days after the bleeding. Alpha 1‐antitrypsin gradually increased for 14 days. Transferrin did not markedly change. The endotoxin‐binding capacity of transferrin and α 1 ‐acid glycoprotein increased immediately after bleeding and thereafter decreased, but that of α 1 ‐antitrypsin tended to increase in the recovery period. In summary, the plasma endotoxin concentration and endotoxin‐binding capacity of α 1 ‐acid glycoprotein and transferrin were shown to have increased after bleeding from varices by this new method. There may be a close relationship between endotoxaemia and acute phase reaction in this situation.