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Histological maturity of healed duodenal ulcer and ulcer recurrence after treatment with omeprazole or cimetidine
Author(s) -
PAN S.,
LIAO C. H.,
LIEN G. S.,
CHEN S. H.
Publication year - 1994
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1994.tb01308.x
Subject(s) - cimetidine , medicine , omeprazole , duodenal ulcer , gastroenterology , surgery
We investigated the relationship between histological maturity of healed duodenal ulcer and ulcer recurrence after treatment with omeprazole or cimetidine for 4 weeks. The healing rates, 92.5 and 72.4% in omeprazole‐treated and cimetidine‐treated groups, respectively, showed no significant difference between groups ( P > 0.05). Histologically, the regenerating mucosa of healed ulcer was divided into three categories: good, fair and poor patterns. Of the healed cases, 22 (59.5%) of 37 omeprazole‐treated and 12 (28.6%) of 42 cimetidine‐treated ulcers achieved a good pattern, showing significant difference between groups ( P = 0.01). The recurrence rate at 3 months showed statistically significant difference ( P < 0.05) between two groups: 5.4% in omeprazole‐treated and 23.8% in cimetidine‐treated patients. During the period between 3 and 6 months after healing, the difference in recurrence rate between omeprazole‐treated and cimetidine‐treated groups was statistically not significant (12.5% and 25%, respectively, P > 0.05), though the cumulative recurrence rate at 6 months showed a significant difference between groups (17.6% vs 44.7%, P = 0.027). All the recurrent cases of both groups had a fair or poor pattern of regenerating mucosa. The difference in recurrence rate was statistically significant between the healed ulcers with a good pattern and that with a fair or poor patterns both at 3 months and between 3 and 6 months after healing ( P > 0.001 in each). We concluded that better histological maturity of regenerating mucosa may contribute to the lower early recurrence in omeprazole‐treated cases than in cimetidine‐treated cases.