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Gastric cytoprotection by amoxycillin in the rat
Author(s) -
LAM SHIUKUM,
CHO CHIHIN,
CHEN BAOWEN,
LAI KAMCHUEN,
CHING CHIKONG,
HO CHUSHEK,
LI YIG
Publication year - 1994
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1994.tb01284.x
Subject(s) - medicine , cytoprotection , helicobacter pylori , gastric mucosa , ex vivo , stomach , pharmacology , intraperitoneal injection , in vivo , antibacterial agent , gastroenterology , antibiotics , microbiology and biotechnology , biology , oxidative stress
Amoxycillin in combination with anti‐ulcer agents has been shown to prolong duodenal ulcer remission. While this effect can be related to the eradication of Helicobacter pylori , it is not known if amoxycillin might possess cytoprotective properties. Protection against ethanol‐induced gastric mucosal damage by intragastric instillation of amoxycillin suspension (prepared from capsule form) and solution (from injection form, 100% pure amoxycillin), and by intraperitoneal injection of amoxycillin solution was studied using an ex vivo gastric chamber in the rat. Intragastric and intraperitoneal administration of amoxycillin dose‐dependently protected the rat gastric mucosa from damage by absolute ethanol. This protection was lost when the rats were pretreated with indomethacin. Gastric mucosal blood flow as measured by laser Doppler flowmetry and gastric acid output were unaffected by amoxycillin. Amoxycillin imparts gastric cytoprotection, and one possible mechanism is by the release of prostaglandins.