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Prolonged bleeding time in cirrhotic patients: Relationship to peripheral vasodilation and severity of cirrhosis
Author(s) -
HSU WANCHING,
LEE FAYAUH,
LEE SHOUDONG,
TSAI YANGTE,
LIN HANCHIEH,
LIN RENSHIN,
MENG HONGCHIANG,
WANG TEHFANG,
WANG SUNSANG,
LO KWANGJUEI
Publication year - 1994
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1994.tb01270.x
Subject(s) - medicine , prothrombin time , cirrhosis , gastroenterology , partial thromboplastin time , bleeding time , vascular resistance , platelet , hemodynamics , platelet aggregation
A prolonged bleeding time (>540 s), measured with a Simplate single template device, was found in 0% of 50 patients with chronic hepatitis and 38% of 154 cirrhotic patients. Cirrhotic patients with a prolonged bleeding time ( n = 59) had lower platelet counts ( P < 0.001) and a longer prothrombin time ( P < 0.001) and activated partial thromboplastin time ( P < 0.001) compared with cirrhotic patients with a normal bleeding time ( n = 95). A weak but significant negative correlation existed between the bleeding time and platelet count in cirrhotic patients ( n = 154, r = ‐0.3668, P < 0.001). Patients with decompensated cirrhosis had a longer bleeding time in comparison to patients with compensated cirrhosis (621±39 vs 478 ± 27 s, respectively, P < 0.01). The prolonged bleeding time was also discovered in 25% of 83 cirrhotic patients with a platelet count >80 × 10 9 /L and a prothrombin time < 17 s (usually taken as safe limits for invasive procedures). Twenty‐seven of the 83 cirrhotic patients received a haemodynamic study by Swan‐Ganz catheterization. A lower systemic vascular resistance was found in cirrhotic patients with an abnormal bleeding time than in cirrhotic patients with a normal bleeding time (844 ± 57 vs 1171 ± 60 dyne·s·cm −5 , respectively, P < 0.001), whereas both groups had similar hepatic venous pressure gradient (16.2 ± 1.2 vs 18.1 ± 1.4 mmHg, respectively, P > 0.05). There was a significant negative correlation observed between systemic vascular resistance and bleeding time in cirrhotic patients with a platelet count >80 × 10 9 /L and a prothrombin time < 17 s ( n = 27, r = ‐0.63, P < 0.001). These results demonstrate that prolonged bleeding time is common in patients with cirrhosis. Peripheral vasodilation is probably an important factor in addition to platelet counts and the severity of liver disease in determining the bleeding time in cirrhosis.