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Reversibility of organic anion‐induced cholestasis: Association with compensatory hypersecretion of biliary phospholipid and protein in the dog
Author(s) -
TAZUMA SUSUMU,
TOKUMO HIRONORI,
YAMASHITA GUNJI,
HORIKAWA KAZUHIKO,
MIURA HIROYUKI,
HIRANO NAOMICHI,
AIHARA NAOKI,
SASAKI MASATOSHI,
TERAMEN KAZUSHI,
OCHI HIDENORI,
YAMASHITA YOSHIFUMI,
OHYA TOSHIHIDE,
KAJIYAMA GORO,
HOLZBACH R. THOMAS
Publication year - 1994
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1994.tb01213.x
Subject(s) - choleretic , cholestasis , medicine , taurocholic acid , endocrinology , sulfobromophthalein , salt (chemistry) , organic anion , biliary tract , micelle , bile acid , gastroenterology , chemistry , ion , liver function tests , organic chemistry , aqueous solution
The effect of a concomitant infusion of organic anions, structurally related phthaleins, on bile flow was studied in anaesthetized dogs. A combination of rose bengal and sulfobromophthalein was found to uniquely and synergistically produce an acute, reversible form of intrahepatic cholestasis (< 10% of control level). This phenomenon was not observed with the administration of those individual organic anions at concentrations previously associated with the induction of intrahepatic cholestasis. The infusion of either a micelle forming bile salt, sodium taurocholate, or a non‐micelle forming bile salt, sodium dehydrocholate, rapidly reversed the intrahepatic cholestasis (within 20 min after bile salt infusion). During the choleretic phase immediately following the bile salt infusion, a transient but marked hypersecretion, a disproportionately increased output in relation to that of bile acids, of biliary phospholipid (176% of control level by taurocholate and 138% of control level by dehydrocholate), and an even more striking amount of biliary protein hypersecretion were observed (392% of control level by taurocholate and 357% of control leverl by dehydrocholate). Although the significance of these new post‐cholestatic observations requires clarification, it is suggested that the intrahepatic cholestasis induced by organic anions reflects a reversible defect in the mechanism(s) involved in transcellular transport.