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Expression of multidrug resistance (P‐glycoprotein) gene in liver cancers
Author(s) -
KUO M. TIEN,
TEETER L. D.,
CURLEY S.,
HSU HC.
Publication year - 1993
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1993.tb01675.x
Subject(s) - multiple drug resistance , p glycoprotein , medicine , gene , drug resistance , gene expression , glycoprotein , transporter , cancer research , hepatocellular carcinoma , membrane glycoproteins , immunology , biology , microbiology and biotechnology , genetics
Hepatocellular carcinomas have been known to exhibit a poor response to chemotherapeutic agents. However, the mechanism for drug resistance is unknown. Recent studies have demonstrated that expression of a group of membrane proteins known as P‐glycoproteins (P‐gp) or multidrug transporters encoded by multidrug‐resistance ( MDR ) or P‐glycoprotein gene family is correlated with a poor clinical prognosis for particular non‐responsive neoplasms. The possible involvement of MDR gene expression with the intrinsic poor response to chemotherapeutic agents is discussed.