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Marked retention of indocyanine green and sulfobromophthalein with chronic persistent hepatitis
Author(s) -
IKEJIMA KENICHI,
ICHIKAWA SHOICHI,
KITAMURA TSUNEO,
WATANABE SUMIO,
HIROSE MIYOKO,
YOKOI YUKIO,
UCHIDA SHIGEYUKI,
OIDE HIROSUMI,
SUZUKI HIDEO,
KITAMI NORIYUKI,
SATO NOBUHIRO
Publication year - 1993
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1993.tb01554.x
Subject(s) - sulfobromophthalein , indocyanine green , medicine , hbsag , liver biopsy , asymptomatic , bilirubin , liver function , excretory system , gastroenterology , hepatitis b , hepatitis b virus , hepatitis , jaundice , liver function tests , biopsy , pathology , immunology , virus
A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface antigen (HBsAg) and antibody to hepatitis B e antigen (anti‐HBe) were positive. A history of drug abuse or alcoholism was denied. Dye excretion tests revealed marked retention of ICG (R 15 = 70%) and BSP (R 45 = 23%). Histopathological examination of a liver biopsy specimen obtained during laparoscopic observation showed chronic persistent hepatitis (CPH). Familial research of the patient failed to prove the existence of dye excretory defect in his siblings. Usual cases of CPH due to continuous HBV infection do not show such severe disturbance of organic anion transport. This pattern of the dye excretory defect with CPH has not been reported. Although the relationship between this dye excretory defect and HBV infection is unclear, the existence of the constitutional dye excretory defect due to abnormal organic anion transport in the liver might be considered.