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Pertussis toxin‐induced redistribution of cortical actomyosin and inhibition of phagocytosis in rat Kupffer cells
Author(s) -
HIROSE MIYOKO,
WATANABE SUMIO,
UENO TAKASHI,
KITAMI NORIYUKI,
SATO NOBUHIRO
Publication year - 1993
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1993.tb01526.x
Subject(s) - phagocytosis , medicine , pertussis toxin , toxin , redistribution (election) , microbiology and biotechnology , immunology , receptor , biology , g protein , politics , political science , law
The mechanism of phagocytosis by Kupffer cells has been shown to be related to the Ca 2+ ‐calmodulin and the actomyosin systems. However the role of the transmembrane signal transmitter, G‐protein, is still unknown. In this study, a quantitative evaluation of phagocytosis by Kupffer cells of rats in culture and the effects of pertussis toxin, a G‐protein inhibitor, on the phagocytic function and morphology of Kupffer cells were investigated. Pertussis toxin inhibited phagocytosis of Kupffer cells with dysfunction of the actomyosin system. The inhibitory effects of pertussis toxin suggest that G‐protein may be involved in the mechanism of transmembrane signalling in phagocytosis by Kupffer cells.