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The protective effect of pyrroloquinoline quinone and its derivatives against carbon tetrachloride‐induced liver injury of rats
Author(s) -
TSUCHIDA TOSHIHIRO,
YASUYAMA TOSHIFUMI,
HIGUCHI KIYOHIRO,
WATANABE AKIHARU,
URAKAMI TEIJI,
AKAIKE TAKAAKI,
SATO KEIZO,
MAEDA HIROSHI
Publication year - 1993
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1993.tb01525.x
Subject(s) - pyrroloquinoline quinone , carbon tetrachloride , biochemistry , chemistry , ccl4 , pharmacology , quinone , medicine , organic chemistry , cofactor , enzyme
Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ‐G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl 4 ) in vivo. This effect was observed after an intraperitoneal injection of 5 mg/kg PQQ or OPQ‐G, which was given twice, 10 min and 1 h before CCl 4 administration. Pyrroloquinoline quinone protected primary cultured rat hepatocytes from CCl 4 toxicity in vitro. This protection was most effective at a concentration of 3 μmol/L PQQ. Pyrroloquinoline quinone derivatives (oxazo pyrroloquinoline, methyl‐thioethyl oxazo pyrroloquinoline and PQQ‐allylester) also protected the hepatocytes from CCl 4 toxicity. Pyrroloquinoline quinone and its derivatives inhibited the lucigenin‐enhanced chemiluminescence from isolated hepatocytes initiated by CCl 4 . These results suggest that eliminating free radicals is one of the protective mechanisms of PQQ and its derivatives against CCl 4 ‐induced liver injury.