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Regional differences in microvascular response in rat intestine during acute elevation of portal pressure
Author(s) -
NAGATA HIROSHI,
SEKIZUKA EIICHI,
MORISHITA TETSUO,
HOUZAWA SHIGENARI,
OSHIO CHIKARA,
MIURA SOHICHIRO,
TSUCHIYA MASAHARU
Publication year - 1993
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1993.tb01520.x
Subject(s) - medicine , portal hypertension , blood flow , submucosa , microcirculation , portal venous pressure , anatomy , hemodynamics , small intestine , blood pressure , laser doppler velocimetry , pathology , cardiology , cirrhosis
The effect of acute elevation of portal pressure on the blood flow of rat intestinal microvessels was studied using a laser Doppler velocimeter and in vivo microscopy. The total intestinal blood flow decreased when portal pressure increased more than + 15 cmH 2 O above the basal value. Blood flow in villus capillaries did not change at portal pressures of + 5 to + 15 cmH 2 O, but did decrease at + 20 cmH 2 O. Blood flow in muscle capillaries decreased at all steps of portal hypertension. Red blood cell velocity was decreased by portal hypertension in large venules, but not in small venules of the submucosa. Large venules, but not small venules, dilated in acute portal hypertension. Large arterioles in the submucosa constricted, while small arterioles dilated at portal pressures of + 10 to + 15 cmH 2 O. In conclusion, the intestinal microvascular flow response differs according to the degree of portal hypertension and the location on the microvascular tree. Blood flow in villus capillaries and in small submucosal venules is maintained at a small degree of portal hypertension.