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Bacterial invasion into the colonic mucosa in ulcerative colitis
Author(s) -
OHKUSA TOSHIFUMI,
OKAYASU ISAO,
TOKOI SHINSUKE,
OZAKI YOSHINORI
Publication year - 1993
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1993.tb01184.x
Subject(s) - ulcerative colitis , medicine , bacteria , acridine orange , intestinal mucosa , colitis , gastroenterology , pathology , staining , microbiology and biotechnology , biology , disease , genetics
This study investigated interactions between mucosal lesions and bacterial invasion in ulcerative colitis using the acridine‐orange staining method. In all 16 cases of ulcerative colitis, the mucosa was found to be invaded by small rods and cocci. In five of 10 controls, bacteria were seen only adhering to the mucosa and no bacteria were detected in the five remaining cases. It is suggested that the presence of bacteria in the colonic mucosa may be a factor responsible for the persistence or aggravation of ulcerative colitis.