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Clinical significance of the serum levels of the 7S domain of type IV collagen in patients with primary biliary cirrhosis
Author(s) -
FUKUTOMI T.,
SAKAMOTO S.,
ISOBE H.,
SAKAI H.,
MASUMOTO A.,
NAWATA H.
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb01492.x
Subject(s) - primary biliary cirrhosis , medicine , cirrhosis , asymptomatic , gastroenterology , biliary cirrhosis , hepatitis , primary sclerosing cholangitis , pathology , autoimmune disease , disease
The serum levels of the 7S domain of type IV collagen were measured with a radio‐immunoassay in 42 patients with primary biliary cirrhosis (asymptomatic: n = 28; symptomatic: n = 14), 10 patients with chronic active hepatitis, 10 patients with liver cirrhosis and 10 healthy female controls. Serum levels of the 7S domain of type IV collagen were: 4.28 ng/mL (3.88–4.72 ng/mL; mean and range of mean ± s.d.) in healthy controls; 5.97 ng/mL (5.07–7.02 ng/mL) in patients with chronic active hepatitis; 8.23 ng/mL (6.40–10.58 ng/mL) in patients with liver cirrhosis; and 6.79 ng/mL (4.76–9.67 ng/mL) in patients with primary biliary cirrhosis. Patients with liver cirrhosis and primary biliary cirrhosis had higher levels of serum 7S domain of type IV collagen than healthy controls ( P < 0.001, respectively). Serum levels of the 7S domain of type IV collagen in patients with asymptomatic primary biliary cirrhosis, 5.83 ng/mL (4.55–7.48 ng/mL) were significantly lower than those in symptomatic primary biliary cirrhosis, 9.18 ng/mL (6.53–12.91 ng/mL; P <0.001). Serum levels of the 7S domain of type IV collagen increased significantly along with advancement of the histological stages of primary biliary cirrhosis. Serum levels of the 7S domain of type IV collagen in the paired sera of eight patients with asymptomatic primary biliary cirrhosis (mean interval 30 months, range 12–48 months) showed significant rises during the intervals ( P < 0.05), while serum levels of albumin and total bilirubin did not change significantly during these intervals. It is concluded that serum levels of the 7S domain of type IV collagen were good markers of fibrosis and may be useful for evaluation of the clinical status in the patients with primary biliary cirrhosis.