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Protective effects of a prostaglandin E 1 oligomer on taurocholate‐induced rat pancreatitis
Author(s) -
SAKAI Y.,
HAYAKAWA T.,
KONDO T.,
SHIBATA T.,
KITAGAWA M.,
SOBAJIMA H.,
NARUSE S.,
OHNISHI S. T.
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb01491.x
Subject(s) - pancreatitis , medicine , acute pancreatitis , oligomer , prostaglandin , pancreas , prostaglandin e , prostaglandin e2 , endocrinology , gastroenterology , chemistry , organic chemistry
Effects of prostaglandin E (PGE) on acute pancreatitis have been controversial. This study shows the effects of PGE 1 oligomer, MR‐356, on trypsin‐taurocholate‐induced acute pancreatitis in rats. Divided intraperitoneal doses of 0.6 mg/rat were administered, which increased 24 h survival rates when the oligomer was given both at 1 h before and after (group A) and immediately and 3 h after (group B) induction of pancreatitis. In group A MR‐356 significantly improved the survival rates at 18 h (94 vs 61%, P < 0.05) and 24 h (68 vs 33%, P <0.05) when compared with controls. MR‐356 improved the survival rates dose‐dependently up to 0.6 mg/rat when given by the same protocol of group A. In group B MR‐356 also improved the survival rate (72 vs 39%, P < 0.05) only at 24 h, while other parameters failed to improve. The present results suggest that the PGE 1 oligomer may play a beneficial role in bile‐induced pancreatitis, probably through its proposed effects of stabilization of lysosomal membranes, maintenance of microcirculation and inhibition of protease in the pancreas.