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Effects of a gastric mucosal protecting agent in rats with liver cirrhosis
Author(s) -
KURIHARA TAKESHI,
AKIMOTO MASUMI,
KUROKAWA KAORI,
ISHIGURO HISATAKA,
NIIMI AKIKO,
MAEDA ATUSHI,
SHIGEMOTO MUTSUO,
YAMASHITA KATSUKO,
YOKOYAMA IZUMI
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb01009.x
Subject(s) - medicine , cirrhosis , gastroenterology , blood flow , transaminase , oral administration , biology , biochemistry , enzyme
Male Sprague–Dawley rats were fed a 0.1% ethionine‐added choline‐deficient diet for 8 weeks to induce liver cirrhosis. At the same time 100 mg/kg/day teprenone was administered orally in order to evaluate its effects on the liver and gastric mucosal blood flow. Blood flow increased not only in gastric mucosa but also in liver tissues in the teprenone group. Serum transaminase levels and histopathologic findings of the liver also improved. These findings suggest that teprenone alleviates hepatocellular injuries. This effect may be partly attributable to cytoprotective effects of the catenoid isoprenoid moiety of teprenone on liver cells.