Premium
Selectivity of serum immunoreactive prolyl 4‐hydroxylase as a marker for hepatic necrosis
Author(s) -
NAGAI YOSHIKI,
KATO MASATOSHI,
TODA GOTARO
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb00974.x
Subject(s) - necrosis , medicine , inflammation , pathophysiology , tumor necrosis factor alpha , alanine aminotransferase , endocrinology , immunoassay , immunohistochemistry , pathology , antibody , immunology
To investigate the selectivity of serum immunoreactive prolyl 4‐hydroxylase (S‐IRPH) as a marker for hepatic necrosis, sera were taken from patients with hepatic inflammation and hepatic necrosis. The concentration of immunoreactive prolyl 4‐hydroxylase in the sera was determined by radio‐immunoassay, and S‐IRPH and alanine aminotransferase (ALT) data were plotted. Patients with hepatic necrosis showed mainly prolyl 4‐hydroxylase elevation while patients with inflammation had both prolyl 4‐hydroxylase and alanine aminotransferase elevations. The addition of serum immunoreactive prolyl 4‐hydroxylase to current serum markers would be useful in investigating the pathophysiology of hepatocellular damage, particularly in differentiating between hepatic necrosis and inflammation.