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Lack of hepatic benefit by oxygen inhalation during vasopressin infusion in patients with cirrhosis
Author(s) -
IWAO TADASHI,
TOYONAGA ATSUSHI,
SUMINO MICHIHIRO,
OHO KAZUHIKO,
SAKAKI MUNENORI,
KEGAMI MOTOKII,
NISHIZONO MASATOSHI,
TANIKAWA KYUICHI
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb00973.x
Subject(s) - medicine , vasopressin , cirrhosis , inhalation , indocyanine green , anesthesia , oxygen , perfusion , hepatic function , venous blood , liver function , surgery , chemistry , organic chemistry
Vasopressin has been found to impair hepatic function in patients with cirrhosis. The aim of this study was to investigate whether oxygen inhalation could improve hepatic function during vasopressin infusion. Vasopressin (0.3iu/min) was infused into eight patients with cirrhosis for 50min. During the first 30min they were ventilated by room air and for the following 20min by oxygen (approximate 50% of FiO 2 ). The extra oxygen inhalation caused a typical increase in arterial (+ 7%, P 0.01), portal venous (+8%, P 0.05), and hepatic venous (+9%, P 0.01) oxygen content. No effect was noted in arterio‐hepatic venous and portal venous‐hepatic venous oxygen content difference in comparison with the values after vasopressin alone. The hepatic perfusion remained unchanged. These results suggest that the extra oxygen did not increase hepatic oxygen uptake. Similarly, intrinsic clearance of indocyanine green did not improve. It is concluded that oxygen supplement in this setting has no hepatic benefit in patients with cirrhosis.