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Evaluation of hepatic transport function by hepatobiliary scintigraphy
Author(s) -
TAKIKAWA HAJIME,
TOMITA JUN,
SEKIYA YUSHI,
MIYAKI KAZUHIKO,
YAMANAKA MASAMI,
NIIO YASUO,
KUNIYASU YOSHIO,
SUGIYAMA YUICHI
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb00954.x
Subject(s) - compartment (ship) , scintigraphy , biliary tract , medicine , gastroenterology , efflux , hepatic function , excretory system , bilirubin , endocrinology , chemistry , biochemistry , oceanography , geology
The transport kinetics of [ 99m Tc]‐pyridoxyl‐5‐methyltryptophan were studied by three‐compartment model analysis for hepatobiliary scintigraphy in 45 patients with chronic viral liver diseases. Three‐compartment model analysis was studied using the time‐activity curves of the regions of the heart, liver, and biliary tract and intestine (excretory compartment). The k 12 (hepatic uptake rate constant), k 21 (hepatic efflux rate constant), and k e1 (hepatic excretion rate constant) were calculated by the nonlinear least‐squares method. Among the three parameters obtained by model analysis, k 12 values more prominently differed among diseases and correlated well with blood tests such as total bilirubin, total bile acids, or 15 min retention of ICG. In conclusion, three‐compartment model analysis of the hepatic handling of [ 99m Tc]‐pyridoxyl‐5‐methyltryptophan is useful in evaluating hepatic transport function. k 12 is the most sensitive parameter for this.