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Effect of glycyrrhizin on lysis of hepatocyte membranes induced by anti‐liver cell membrane antibody
Author(s) -
SHIKI YASUKO,
SHIRAI KOHJI,
SAITO YASUSHI,
YOSHIDA SHO,
MORI YOSHIO,
WAKASHIN MASAFUMI
Publication year - 1992
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1992.tb00927.x
Subject(s) - glycyrrhizin , transaminase , hepatocyte , antibody , alanine transaminase , aspartate transaminase , biochemistry , cell , phospholipase a2 , microbiology and biotechnology , liver cell , phospholipase , cell membrane , pharmacology , medicine , enzyme , endocrinology , chemistry , biology , immunology , in vitro , alkaline phosphatase
Studies were made on why glycyrrhizin injection decreases the plasma aspartate aminotransferase (AST) and alanine aminotransferase activities in patients with chronic hepatitis. 1 For this, rat hepatocytes were isolated, and incubated with antibody raised against rat liver cell membranes, and the effect of glycyrrhizin on their release of transaminase was investigated. Isolated rat hepatocytes released AST on incubation with anti‐liver cell antibody in the presence of complement. At this time, their endogenous phospholipase A 2 activity was increased. Cultured hepatocytes also released the transaminase in the presence of venom phospholipase A 2 . Glycyrrhizin suppressed the release of transaminase in the presence of either anti‐liver cell membrane antibody or phospholipase A 2 . These results suggest that antibody treatment raised the phospholipase A 2 activity in liver cell membranes, resulting in release of transaminases, and that glycyrrhizin suppressed this increase in phospholipase A 2 activity and so inhibited the release of transaminase.