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Dual colour fluorescein analysis of peripheral blood T cells in auto‐immune chronic active hepatitis
Author(s) -
KATOH TATSUKO,
YAMAUCHI KATSUMI,
HAYASHI NAOAKI,
OBATA HIROSHI
Publication year - 1991
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1991.tb01476.x
Subject(s) - immune system , cd8 , medicine , immunology , hepatitis , antigen , t cell
Both CD4 and CD8 T cells are subdivided into two phenotypically distinct sublineages via another two T cell markers, Leu‐8 and CD11b antigens. The proportions of these four T cell subsets, CD4 + Leu8 + , CD4 + Leu ‐8 , CD8 + 11b + and CD8 + 11b ‐ , were studied in patients with auto‐immune chronic active hepatitis (CAH) and compared with disease controls (hepatitis B surface antigen positive chronic active hepatitis) and healthy controls. We found that the proportion of CD4 + Leu8 + cells was significantly reduced compared with controls ( P < 0.01), whereas those of the other cells were almost identical in all 3 groups. The absolute number of these CD4 + Leu8 + cells was also lower than that of controls ( P < 0.01). Thus, the present study suggests that a reduced number of CD4 + Leu8 + cells is associated with the aberrant immune response in auto‐immune CAH.