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A double‐blind study of misoprostol (SC‐29333) in the healing of duodenal ulcer
Author(s) -
AHMED WAQARUDDIN,
QURESHI HUMA,
ALAM EJAZ,
ZUBERI SARWAR J.
Publication year - 1991
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1991.tb01463.x
Subject(s) - medicine , misoprostol , placebo , double blind , placebo group , itching , surgery , duodenal ulcer , placebo controlled study , gastroenterology , pregnancy , genetics , alternative medicine , pathology , abortion , biology
In a double‐blind randomized placebo controlled trial, 50 patients with endoscopically confirmed duodenal ulcer were treated with either misoprostol 200 μg or placebo in q.i.d. doses for 4–8 weeks. Of 25 patients in the placebo group, four defaulted and two were withdrawn due to worsening of symptoms. Of 25 misoprostol‐treated cases, 17 cases (68%) and 21 cases (84%) healed at 4 and 8 weeks respectively, compared with three (14%) and five (24%) of the 21 placebo‐treated cases ( P < 0.001). Except for diarrhoea in 2 patients in each group and itching in one with misoprostol, no serious side effects were noted.