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Effect of verapamil on splanchnic haemodynamics in a portal hypertensive rat model
Author(s) -
LAY CHIISHYAN,
TSAI YANGTE,
YANG CHUENMAY,
CHEN HSINGI.,
SIMCHON SHLOMOH,
CHIEN SHU,
LO KWANGJUEI
Publication year - 1990
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1990.tb01819.x
Subject(s) - verapamil , medicine , portal venous pressure , portal hypertension , splanchnic , hemodynamics , vascular resistance , cirrhosis , cardiology , blood pressure , cardiac output , anesthesia , calcium
To elucidate the effects of verapamil on splanchnic haemodynamics in rats with portal hypertension, verapamil was given at a low dose (0.2 mg/kg) and a high dose (2 mg/kg) to the rat model after portal vein ligation. Approximately 10% decrease in arterial pressure was caused by the low dose of verapamil, with significant decreases in cardiac output and portal venous inflow as well as reduced portal pressure; these were all indicative of a rise in portal vascular resistance. In contrast, the marked fall in both arterial pressure and cardiac output in the high dose, accompanied by a significant decrease in the portal pressure and the unchanged portal venous inflow, suggested a reduction in portal vascular resistance. This study shows that the acute effects of verapamil on portal hypertension may vary with the dosage used. These results also demonstrate that, since the therapeutic efficacy and safety of verapamil is only in a very limited range of dose, caution should be taken in its clinical use in the treatment of cirrhosis with portal hypertension.