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Hepatic toxicity of Vitamin A and synthetic retinoids
Author(s) -
FALLON MICHAEL B.,
BOYER JAMES L.
Publication year - 1990
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1990.tb01635.x
Subject(s) - hypervitaminosis a , medicine , hypervitaminosis , toxicity , vitamin , liver toxicity , chronic toxicity , retinoid , physiology , retinoic acid , retinol , biochemistry , chemistry , gene
Vitamin A and synthetic retinoids have recently been used increasingly in a variety of health related concerns. Hepatic toxicity is an uncommon but serious side‐effect of several Vitamin A derivatives which may lead to cirrhosis. This review will focus on the clinical and pathologic findings of hepatic involvement in chronic hypervitaminosis A and on the evidence concerning the potential hepatotoxicity of currently available synthetic retinoids.