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Portal circulation in monkeys and humans studied after ingestion of a capsule containing a radionuclide
Author(s) -
SHIOMI SUSUMU,
KUROKI TETSUO,
UEDA TADASHI,
NISHIGUCHI SHUHEI,
NAKAJIMA SHINYA,
KOBAYASHI KENZO,
KURAI OSAMU,
IKEOKA NAOKO,
MONNA TAKEYUKI,
OCHI HIRONOBU
Publication year - 1990
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1990.tb01621.x
Subject(s) - medicine , mesenteric vein , scintigraphy , capsule , superior mesenteric vein , blood flow , nuclear medicine , inferior mesenteric vein , technetium 99 , small intestine , technetium , pertechnetate , splenic vein , technetium 99m , radiology , portal vein , portal hypertension , botany , cirrhosis , biology
Capsules (8 times 30 mm) of technetium‐99m pertechnetate were designed for measurement of portal blood flow. Most of the radionuclide entered the superior mesenteric vein. The capsule was taken orally and monitored with a collimator for scintigraphy until it reached the small intestine, when a magnetic field completed an electrical circuit in a sensor, burning a thread, releasing a spring, and discharging the preparation. A study in crab‐eating monkeys (Macaca fascicularis) showed that the radionuclide in the small intestine circulated through the superior mesenteric vein to the portal vein and liver. Portal scintigraphy through the small intestine could be analysed in the same way as per‐rectal portal scintigraphy, in which blood flow mostly from the inferior mesenteric vein is evaluated. A study of four volunteers showed that, after the radionuclide was released, it circulated through the superior mesenteric vein to the portal vein and liver. Use of a capsule enclosing a radioisotope was possible, and the procedure seemed to be safe. The use of the per‐small intestine method plus the per‐rectal method should give more accurate results than either method used alone, because the haemodynamics of both the superior and inferior mesenteric vein would be reflected.