Premium
Chronic hepatitis with fatty change
Author(s) -
ALVAREZ SOL Z.,
BILLOTE JUANITO,
ONGKINGCOOBILLOS CYNTHIA
Publication year - 1990
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1990.tb01620.x
Subject(s) - medicine , cirrhosis , liver biopsy , gastroenterology , alcoholic hepatitis , hepatitis , steatohepatitis , ingestion , fatty liver , chronic hepatitis , biopsy , serology , toxic hepatitis , hepatitis b , alcoholic liver disease , immunology , antibody , disease , virus
Ten patients with clinical features of chronic hepatitis showed on liver biopsy histologic evidence of chronic hepatitis plus predominantly moderate to severe fatty change. No patient had a history of excess alcohol intake, or prolonged intake of hepatotoxic drugs and steroids, and were not obese or malnourished. These cases differ from the reported cases of non‐alcoholic steatohepatitis resembling alcoholic hepatitis as they occurred in relatively young healthy adults, predominantly males, who were not diabetic or obese. Mallory's hyalin in liver was absent in all cases. Ingestion of toxic substances was possible but no history was obtained to account for it. While these could be unusual cases of chronic non‐A, non‐B hepatitis, this can be only speculation until a serologic test for non‐A, non‐B hepatitis becomes available. Follow‐up of eight patients for 1–3 years with liver biopsy showed that they had a relatively benign course with no evidence of progression to cirrhosis.