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Antipyrine elimination test as a guideline for selecting patients for transhepatic biliary drainage
Author(s) -
RAMESH V. S. V.,
KOCHHAR R.,
GARG S. K.,
WIG J. D.,
GUPTA N. M.
Publication year - 1990
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1990.tb01619.x
Subject(s) - medicine , bilirubin , biliary drainage , obstructive jaundice , alkaline phosphatase , jaundice , gastroenterology , albumin , liver function , percutaneous , guideline , decompression , liver function tests , surgery , pathology , enzyme , biochemistry , chemistry
Antipyrine elimination halflife (AP t 1/2 ) was studied in 18 patients with obstructive jaundice along with routine liver function tests 24–48 h before the expected time of percutaneous transhepatic biliary drainage (PTBD). To see if it is possible to predict the outcome of PTBD, various predrainage parameters were correlated with the postdrainage bilirubin clearance after 1 week of drainage. Predrainage AP t 1/2 correlated best with bilirubin clearance ( r = 0.775, P <0.01) compared with predrainage serum bilirubin, alkaline phosphatase and serum proteins/albumin. Eight patients had AP t 1/2 < 15 h, while 10 had AP t 1/2 15 h. Patients with AP t 1/2 < 15 h had significantly faster recovery after PTBD than patients with AP t 1/2 > 15 h. If PTBD can be restricted to those with AP t 1/2 < 15 h, the advantages of preliminary PTBD can be achieved with minimum complications. Thus, estimation of AP t 1/2 may aid in the selection of patients with obstructive jaundice who are likely to benefit by preliminary biliary decompression.