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Portal vein obstruction complicating intra‐arterial chemo‐infusion for hepatic metastases
Author(s) -
TAKAYASU KENICHI,
MAKUUCHI MASATOSHI,
MORIYA YOSHIHIRO
Publication year - 1990
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1990.tb01131.x
Subject(s) - medicine , portal vein thrombosis , radiology , vein , portal venous pressure , thrombosis , esophageal varices , hepatic arterial infusion , surgery , colorectal cancer , portal vein , cancer , portal hypertension , gastroenterology , cirrhosis
In three patients with colon cancer and liver metastases who had received intra‐arterial chemo‐infusion of fluorouracil (5FU) and mitomycin C and/or cis ‐diamminedichloroplatinum (CDDP), intrahepatic portal vein thrombosis (PVT) was incidentally demonstrated by computerized tomography (CT) 6, 1 and 7 months respectively after the cessation of administration of anti‐cancer agents. One patient developed complete PVT in the whole liver as shown by follow‐up CT 6 months after a diagnosis of pre‐existing sclerosing cholangitis, and died from rupture of oesophageal varices. In the remaining two patients, PVT was found incidentally by follow‐up CT in the right portal vein (Case 2) and the right anterior portal vein (Case 3) respectively; it spontaneously recanalized in Case 2 and was still present in Case 3 2 months later. PVT seems to be one of the complications of hepatic arterial chemo‐infusion and its possibility must be borne in mind in such patients, even though the exact interval between the arterial chemo‐infusion and occurrence of PVT could not be determined.