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Applications of molecular genetics to gastrointestinal and liver diseases. II. Clinical relevance
Author(s) -
SUMMERS KIM M.
Publication year - 1989
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1989.tb00835.x
Subject(s) - medicine , cystic fibrosis , familial adenomatous polyposis , disease , clinical significance , prenatal diagnosis , gastrointestinal disease , gastrointestinal tract , liver disease , bioinformatics , pathology , cancer , colorectal cancer , genetics , gastroenterology , pregnancy , biology , fetus
Abstract The use of DNA probes within or near disease genes is becoming increasingly important in clinical medicine. Probes are available for prenatal and carrier diagnosis for several of the more than 100 genetic diseases of the gastrointestinal tract and liver. These include familial adenomatous polyposis, haemochromatosis, cystic fibrosis, α 1 ‐antitrypsin deficiency and the hereditary porphyrias. This review uses examples drawn from such diseases to show the relevance of these approaches to the clinician.