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Effect of smoking on gastric acid secretion in patients with duodenal ulcer
Author(s) -
RAMESH G. N.,
KOCHHAR R.,
BROOR S. L.,
GHOSH P.,
SHARMA B. K.,
MEHTA S. K.
Publication year - 1989
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1989.tb00833.x
Subject(s) - medicine , duodenal ulcer , gastroenterology , gastric acid , secretion , gastric secretion , duodenum , general surgery
Abstract The effect of smoking on gastric secretion was studied in 15 consecutive patients with duodenal ulcer – six normosecretors (basal acid output ≤ 3 mEq/h), and nine hypersecretors (basal acid output > 3 mEq/h). The volume, acid output, acid concentration, and pH of the gastric juice measured before, during and after 1 h of smoking did not show any significant difference in these patients taken as a single group, or when the normosecretors and hypersecretors were analysed as separate groups ( P > 0.05 for each parameter in each group). The higher acid output before and during smoking in hypersecretors than in normosecretors was due to the higher acid concentration in the gastric juice ( P < 0.01). Study of the pH curves of the gastric juice after acute smoking showed that hypersecretors had a lower pH for a longer duration compared with normosecretors. This could make the hypersecretors with a history of chronic smoking more prone to developing duodenal ulcer.