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Gastrin and somatostatin cells in dyspeptic patients with and without duodenal ulcer: A quantitative study based on multiple biopsy specimens
Author(s) -
JIE CHEN,
TONGHUA LIU,
SHENGFANG YE,
CHANGFANG GU,
SHOUPO CHEN
Publication year - 1989
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1989.tb00805.x
Subject(s) - somatostatin , gastrin , medicine , gastroenterology , biopsy , radioimmunoassay , duodenal ulcer , endocrinology , delta cell , hormone , secretion , glucagon
Abstrat The numbers of immunoreactive gastrin and somatostatin cells in gastric and duodenal mucosal biopsy specimens from dyspeptic patients with duodenal ulcers and dyspeptic controls without ulcers were calculated using a morphometric method. The levels of gastrin and somatostatin in the tissue were also measured by the radioimmunoassay. The results showed no significant difference in the number of G cells and the level of gastrin in the tissue between the ulcer and non‐ulcer groups. However, the number of D cells and the level of somatostatin in the tissue in ulcer patients were remarkably reduced in comparison with those in non‐ulcer patients ( P < 0.01 and P < 0.05, respectively). The G: D cells and gastrin: somatostatin ratios in ulcer patients were much higher than those in the non‐ulcer control group. It is considered that the reduction of D cells and the relative lack of somatostatin in duodenal ulcer patients might have a role in the mechanism of the duodenal ulceration.