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Deficiency of endogenous prostanoids in gastric and duodenal ulcer diseases
Author(s) -
ARAKAWA TETSUO,
NAKAMURA HAJIME,
SATOH HIROSHI,
FUKUDA TAKASHI,
SAKUMA HIROYUKI,
KOBOYASHI KENZO
Publication year - 1988
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1988.tb01399.x
Subject(s) - medicine , gastric mucosa , antrum , gastroenterology , prostaglandin e , pyloric antrum , thromboxane , biopsy , stomach , prostaglandin , duodenum , thromboxane b2 , duodenal ulcer , prostaglandin e2 , platelet
The levels of prostaglandin E 2 (PGE 2 ), 6‐keto‐prostaglandin F 1 α (PGF 1 α) and thromboxane B 2 (TXB 2 ) in endoscopic biopsy specimens from the gastric and duodenal mucosa of healthy volunteers and ulcer patients were measured by radio‐immunoassay. The PGE 2 and PGF 1 α levels in the mucosa of the corpus of the stomach were lower and the TXB 2 level was higher in 10 patients with gastric ulcer in the corpus than in the 16 healthy subjects. The PGE 2 level in the antral mucosa of 14 patients with gastric ulcer in the antrum was lower than in the controls. In 18 patients with duodenal ulcer, PGE 2 deficiency was more widespread in the entire gastric and duodenal mucosa while the reduced PGF 1 α level was limited in the gastric corpus. Lower levels of PGE 2 in patients with antral or duodenal ulcer and of PGE 2 and PGF 1 α in patients with corpus ulcer in the anatomical mucosal area including the ulcer site may predispose the mucosa to ulceration.