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Influence of intraduodenal chenodeoxycholic acid on secretory and pressure activity of the stomach and duodenum
Author(s) -
EYREBROOK I. A.,
READ N. W.,
BROWNSON A.,
JOHNSON A. G.
Publication year - 1988
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1988.tb00785.x
Subject(s) - duodenum , medicine , chenodeoxycholic acid , gastroenterology , stomach , gastric acid , saline , migrating motor complex , bile acid , antrum , endocrinology
The influence of duodenal infusion of bile acid at a concentration similar to that in the common bile‐duct (50 mmol/1) on antroduodenal motility, duodenogastric reflux, gastric and duodenal secretion was studied in 10 healthy volunteers. Intraluminal pressures were recorded in the antrum and the first and second parts of the duodenum. Gastric and distal duodenal contents were collected by continuous low pressure sump aspiration during infusion of either saline or chenodeoxycholic acid (CDC) into the second part of the duodenum. Values for duodenogastric reflux and gastric and duodenal secretion were calculated with reference to the recovery of two non‐absorbable markers infused into the stomach and second part of the duodenum. Each volunteer received at least 3 h of saline infusion and 2 h of CDC infusion. During saline infusion, duodenogastric reflux varied with the migrating motor complex (MMC), being statistically greater at the end of duodenal phase III activity than at other times ( P <0.05). Infusion of CDC abolished the MMC and inhibited antral contractions but the amount of reflux was not increased compared with the saline period. Infusion of CDC also produced marked increases in measured bicarbonate ( P <0.001), trypsin ( P <0.001), phospholipase A 2 ( P <0.05) and endogenous total bile acid ( P <0.05) in the duodenum, although gastric acid secretion was unaffected. These findings suggest that bile acid may regulate gastroduodenal motor activity and pancreaticobiliary secretion.